Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia

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Teaching NeuroImages: Nonfluent variant primary progressive aphasia

A 66-year-old woman presented with 4 years of progressive speech difficulty. She had nonfluent speech with phonemic errors but intact single-word comprehension and object knowledge. Her grammar was impaired in both speech and writing, and she exhibited orofacial apraxia. A clinico-radiologic (see figure) diagnosis of nonfluent variant primary progressive aphasia was made. Nonfluent variant prim...

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IMPORTANCE Grammatical comprehension difficulty is an essential supporting feature of the non-fluent/agrammatic variant of primary progressive aphasia (naPPA), but well-controlled clinical measures of grammatical comprehension are unavailable. OBJECTIVE To develop a measure of grammatical comprehension and examine this comparatively in PPA variants and behavioural-variant frontotemporal degen...

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Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia.

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Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia

BACKGROUND/AIMS Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis. METHOD We assessed grammat...

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Treatment for Apraxia of Speech in Nonfluent Variant Primary Progressive Aphasia

There is a growing body of literature examining the utility of behavioral treatment in primary progressive aphasia (PPA). There are, however, no studies exploring treatment approaches to improve speech production in individuals with apraxia of speech (AOS) associated with the nonfluent variant of PPA. The purpose of this study was to examine a novel approach to treatment of AOS in nonfluent PPA...

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ژورنال

عنوان ژورنال: Alzheimer's Research & Therapy

سال: 2018

ISSN: 1758-9193

DOI: 10.1186/s13195-018-0393-8